Where does Botox go once it wears off and when it wears off will it make me look older?

Dr. Jacob Sedgh, MD
Medically reviewed by
Dr. Jacob Sedgh, MD
Double Board-Certified Facial Plastic Surgeon
Botox is widely considered the most effective cosmetic injectable for wrinkle relaxation. It’s composed of a neurotoxin that blocks communications from the nerve endings to the targeted facial muscles responsible for your dynamic wrinkles, such as the forehead lines, frown lines, and crow’s feet. As such, Botox injections suppress the targeted wrinkles, making you look younger. Botox has a lifetime of 3 to 4 months, after which the results dissipate. Once the Botox wears off, you need maintenance doses to retain the results. There’s a common misconception that Botox makes you look older when it wears off. On the contrary, regular Botox treatments make you look younger even after the neurotoxin wears off. This article highlights the aftermath of Botox—where it goes once the results wear off, what happens to your face when the results dissipate, how you can prolong the results, and what you can do after the Botox wears off.

Where does Botox go when it wears off?

The neurotoxin protein in Botox blocks neurotransmitters from engaging with your facial muscles. Over time, the Botox components are broken down into harmless particles called amino acids. The broken-down components are excreted from the kidneys as waste, or they’re used in other proteins. As such, Botox either leaves your system completely or gets recycled in a harmless form.

What happens to your face when Botox wears off?

When the Botox wears off, the neurotransmitters engage the facial muscles again, making the associated wrinkles appear on your face again. As such, the gradual dissipation of Botox leads to a reemergence of facial wrinkles, such as the forehead lines, frown lines between the eyebrows, and the crow’s feet around the eyes. However, you don’t look older than before — on the contrary, you might even look younger. Botox has a prophylactic effect, i.e., besides treating wrinkles, it can also prevent them from appearing. Dynamic wrinkles appear because of the overuse of facial muscles. Over time, as you overuse the muscles responsible for frowning, laughing, etc., the associated wrinkles deepen and become larger. This makes them stay on your face even when you have a neutral look.   However, Botox injections temporarily paralyze the facial muscles. And just like all other muscles, sustained periods of disuse weaken the muscles, making them smaller. As such, if you get Botox injections regularly, the associated wrinkles will fade away permanently. That’s why you can also opt for Botox injections if you don’t have wrinkles — it will help you stay youthful longer. Schedule a consultation today!
Facial Rejuvenation

Botox and Derma Filler

A beautiful example of non-surgical facial rejuvenation done with Botox and DermalFiller

Frequently Asked Questions

The lifetime of Botox is about 3 to 4 months. As far as major fillers, they have different life expectancies. For example, hyaluronic acid fillers such as Voluma, Resylane, and Juvederm are expected to last about one year. Sculptra might last a bit longer, but it is controversial. Radiesse is more or less similar to hyaluronic-based fillers, with about one year of expectancy.

Dermal fillers, especially hyaluronic acid fillers, are gradually broken down and absorbed by the body over time. Botox does not “dissolve” like filler. Its effect wears off as the treated nerve endings recover and muscle activity slowly returns, which is why results usually last about 3 to 4 months. For more insight into the difference between Botox and filler risks, you can also read Dr. Jacob Sedgh’s RealSelf answer.

Botox is not thought to build up in the body in the way filler adds volume. Its cosmetic effect is temporary because nerve signaling gradually recovers, so muscle movement returns over time.

When Botox wears off, the treated muscles gradually regain movement, so lines typically return to their pre-treatment appearance rather than becoming worse because of Botox itself.

When Botox is used correctly over time, serious long-term side effects are considered uncommon. Most side effects are temporary, such as eyelid drooping, headache, or injection-site discomfort.If you want to better understand whether Botox can have lasting muscular effects, check out this RealSelf Q&A.

Posted on behalf of Sedgh Plastic Surgery

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When under our care, Dr. Sedgh always ensures you feel comfortable, cared for, well-informed about every aspect of your upcoming treatment, whether surgical or non-surgical. With an approach which focuses on achieving refreshed, natural-looking results, Dr. Sedgh prides himself on always acting with transparency, honesty, and the highest level of ethical treatment, from start to finish.